karma-ie-launcher
Launcher for Internet Explorer.
Installation
The easiest way is to keep karma-ie-launcher as a devDependency, by running
npm install karma-ie-launcher --save-dev 
Configuration
// karma.conf.js
module.exports = function(config) {
  config.set({
    browsers: ['IE']
  });
}; 
You can pass list of browsers as a CLI argument too:
karma start --browsers IE 
You can run IE in emulation mode by setting the 'x-ua-compatible' option:
customLaunchers: {
  IE9: {
    base: 'IE',
    'x-ua-compatible': 'IE=EmulateIE9'
  },
  IE8: {
    base: 'IE',
    'x-ua-compatible': 'IE=EmulateIE8'
  }
} 
See Specifying legacy document modes on MSDN.
Running IE in "No add-ons mode"
Please note that since v0.2.0 default behaviour of launching Internet Explorer has changed. Now it runs using system-wide configuration (uses same settings as if you would run it manually) but prior to v0.2.0 it was spawned with -extoff flag set explicitly, so all extensions were disabled.
If you expect the same behaviour as it was before v0.2.0, Karma configuration should be slightly changed:
- create new 
customLauncherconfiguration (IE_no_addonsis used in an example below) with custom flags (in our case it is-extoffonly) - browser 
IEinbrowsersfield should be replaced with your new custom launcher name 
  browsers: ['IE_no_addons'],
  customLaunchers: {
    IE_no_addons: {
      base:  'IE',
      flags: ['-extoff']
    }
  } 
See IE Command-Line Options on MSDN.
For more information on Karma see the homepage.